Hi.
I had exactly the same problem a while ago and also other usb devices were acting randomly strange.
The issue for me was that there were too many devices on the USB2 hub (powered). I had to remove my autoguider (especially the QHY5L-II uses all that 2.0 bandwith...) and put it on a direct cable to the computer.
Since then not one issue.
Kind regards, Graem