I ran into this issue again last night. I go to start a sequence and after a short time SGP reports "PHD2 Profile "refreshing" is not valid".
Then SGP pretty much freezes up and I have to start over.
I posted on this before but may have been in the wrong (Hardware) section.
Here is the log file. Trouble starts near the end. Its pretty short.
https://www.dropbox.com/s/l4g99i8zs5qioad/sg_logfile_20160915204428.txt?dl=0