Just figured I would mention that I ran both 2.5.2.1 and the latest PhD2 build and GNS beta last night and it was completely flawless with only the "not dithering after first frame" as an issue. That was solved with a dummy 30 second first exposure. Looking great and very stable on Windows 10 Pro.
SBIG 8300M with self-guide filter wheel
Paramount ME Direct Guide (older version of TSX w/o the synch issue)
Starlight Focuser
Pinpoint with USNO V2