Most probably you got hit by the „Profile as a Template Paradigm“.
Profiles are not what you would expect them to be. They are actually templates, used only to fill-in default values when you create a new sequence. You can change the information such transferred from a profile to a sequence using the Control Panel and these changes will be saved in the actual sequence without touching other sequences.
Editing profiles does not change existing sequences at all. But you can use the command “Apply Profile to sequence” to – well – apply a profile to the actual sequence.
This is by design. You will get used to it.
Regards,
Horia