Ok, I think I'm starting to understand what is going on.
Generally correct but maybe the semantics are wrong. Once you create a sequence with a profile the profile is no longer in play. It is linked to the sequence but if you change the profile any sequences created with that profile won't get automatically updated to the new profile. It's a one way settings "dump" from profile to sequence. I don't think this has anything to do with the issue...just explaining it.
Is it possible that the sequence initially was created with the TMB profile and that later you switched it over to the Edge profile? If you create a new sequence with the Edge profile and reopen it does it show the TMB profile? Essentially can you duplicate this with using a new profile?
Thanks,
Jared